S1PR1 Radioligand 1

Names

[ CAS No. ]:
2845249-11-6

[ Name ]:
S1PR1 Radioligand 1

Biological Activity

[Description]:

S1PR1 Radioligand 1(compound 6 h) is a specific S1PR1 radioligand with IC50 = 8.7 nM. S1PR1 Radioligand 1 has good brain uptake and can be used as a S1PR1-specific F-18 radiotracer for studying the function of S1PR1 in brain diseases[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> GPCR/G Protein >> LPL Receptor

[In Vivo]

S1PR1 Radioligand 1(compound 6 h) 在 SD大鼠的肺、肝和肾中摄取相对较高。其中肺摄取最高，为 9.32±0.94 (%ID/g)，其次为肝脏、肾脏、脾脏、胰腺、心脏和小肠，分别为 4.57±0.16、3.57±0.17、1.90±0.32、1.68±0.14、1.41±0.10和1.06±0.19(%ID/g)[1]。

[References]

[1]. Lin Qiu, et al. Discovery of a Promising Fluorine-18 Positron Emission Tomography Radiotracer for Imaging Sphingosine-1-Phosphate Receptor 1 in the Brain. J Med Chem. 2023 Mar 16.   

Chemical & Physical Properties

[ Molecular Formula ]:
C22H22F5N3O3

[ Molecular Weight ]:
471.42

Related Compounds