BRD4-IN-4

Names

[ Name ]:
BRD4-IN-4

[Synonym ]:
1-ethyl-6-(pyrrolidin-1-ylsulfonyl)benzo[cd]indol-2(1H)-one
1-Ethyl-6-(1-pyrrolidinylsulfonyl)benzo[cd]indol-2(1H)-one
1-Ethyl-6-(pyrrolidine-1-sulfonyl)-1H-benzo[cd]indol-2-one
Benz[cd]indol-2(1H)-one, 1-ethyl-6-(1-pyrrolidinylsulfonyl)-

Biological Activity

[Description]:

BRD4-IN-4 (Compound 1) is a BRD4 inhibitor (IC50=6.83 μM). BRD4-IN-4 selectively inhibits MV4-11 cell line proliferation and arrests cell at G1 phase. BRD4-IN-4 can be used for research of MLL leukemia[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

IC50: 6.83 μM (BRD4)[1]

[References]

[1]. Feng Y, et al. Design, synthesis and biological evaluation of benzo[cd]indol-2(1H)-ones derivatives as BRD4 inhibitors. Eur J Med Chem. 2018 May 25;152:264-273.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
559.0±56.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₈N₂O₃S

[ Molecular Weight ]:
330.40

[ Flash Point ]:
291.8±31.8 °C

[ Exact Mass ]:
330.103821

[ LogP ]:
1.80

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.675