Glycolate oxidase-IN-1

Names

[ CAS No. ]:
330977-65-6

[ Name ]:
Glycolate oxidase-IN-1

Biological Activity

[Description]:

Glycolate oxidase-IN-1(compound 26), a salicylic acid derivative, is a glycolate oxidase (GO) inhibitor with an IC50 of 38.2 μM. Glycolate oxidase-IN-1 has the ability to reduce oxalate production in hyperoxalate hepatocytes and can be used in the study of primary hyperoxaluria type 1 (PH1)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[In Vitro]

Glycolate oxidase-IN-1(compound 26)(0-12.5 μM, 48 h)处理小鼠肝细胞，在浓度为 6.25 μM 时，排出的草酸盐水平显着降低 67.3 ± 32%。在 12.5 μM 的浓度下，处理 24 小时和 48 小时后分别减少105.8 ± 29.2% 和 62.3 ± 24.4%，且没有任何细胞毒性[1]。

[References]

[1]. María Dolores Moya-Garzón, et al. Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1. J Med Chem. 2018 Aug 23;61(16):7144-7167.  

Chemical & Physical Properties

[ Molecular Formula ]:
C12H8O5

[ Molecular Weight ]:
232.19

Related Compounds