Triamcinolone acetonide-d6

Names

[ CAS No. ]:
352431-33-5

[ Name ]:
Triamcinolone acetonide-d6

[Synonym ]:
(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-Fluoro-6b-glycoloyl-5-hydroxy-4a,6a-dimethyl-8,8-bis[(2H3)methyl]-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxo l-2-one
2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4b-fluoro-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(2-hydroxyacetyl)-4a,6a-dimethyl-8,8-di(methyl-d3)-, (4aS,4bR,5S,6aS,6bS,9a R,10aS,10bS)-

Biological Activity

[Description]:

Triamcinolone acetonide-d6 is deuterium labeled Triamcinolone acetonide.

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Endocrinology
Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. http://en.wikipedia.org/wiki/Triamcinolone_acetonide

[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[3]. Zhen Xiang, et al. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. Int J Biol Sci 2020; 16(13):2382-2391.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
576.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H25D6FO6

[ Molecular Weight ]:
440.53

[ Flash Point ]:
302.7±30.1 °C

[ Exact Mass ]:
440.248138

[ LogP ]:
2.50

[ Vapour Pressure ]:
0.0±3.6 mmHg at 25°C

[ Index of Refraction ]:
1.589

Related Compounds