trans-Cinnamic acid-d5

Names

[ CAS No. ]:
352431-48-2

[ Name ]:
trans-Cinnamic acid-d5

Biological Activity

[Description]:

trans-Cinnamic acid-d5 is the deuterium labeled trans-Cinnamic acid[1]. trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1[2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Yilmaz S, et al. Antimicrobial activity of trans-cinnamic acid and commonly used antibiotics against important fish pathogens and nonpathogenic isolates. J Appl Microbiol. 2018 Sep 4.  

Chemical & Physical Properties

[ Molecular Formula ]:
C9H3D5O2

[ Molecular Weight ]:
153.18900

[ Exact Mass ]:
153.08400

[ PSA ]:
37.30000

[ LogP ]:
1.78440

Related Compounds