PIPES-d18

Names

[ CAS No. ]:
352534-95-3

[ Name ]:
PIPES-d18

Biological Activity

[Description]:

PIPES-d18 is the deuterium labeled PIPES[1]. PIPES (1,4-Piperazinediethanesulfonic acid) is an important component of PIPES buffer agent used in biochemistry[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Jason Moggridge, et al. Sensitive Detection of Immunoglobulin G Stability Using in Real-Time Isothermal Differential Scanning Fluorimetry: Determinants of Protein Stability for Antibody-Based Therapeutics. Technol Cancer Res Treat. 2017 Dec;16(6):997-1005.  

Chemical & Physical Properties

[ Melting Point ]:
>300ºC

[ Molecular Formula ]:
C8D18N2O6S2

[ Molecular Weight ]:
320.47900

[ Exact Mass ]:
320.17400

[ PSA ]:
131.98000

[ LogP ]:
0.41700

Related Compounds