LP-471756

Names

[ CAS No. ]:
413605-11-5

[ Name ]:
LP-471756

Biological Activity

[Description]:

LP-471756 is a potent GPR139 antagonist with an IC50 value of 640 nM. LP-471756 inhibits LP-360924-stimulated cAMP production[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GPR139
Research Areas >> Neurological Disease

[Target]

IC50: 640 nM (GPR139)[1]


[In Vitro]

LP-471756 (0-1000 µM) 特异性抑制 GPR139 细胞中 LP-360924 刺激的 cAMP 的生成，IC50 值为 0.64 µM[2]。

[References]

[1]. Vedel L, et al. Pharmacology and function of the orphan GPR139 G protein-coupled receptor. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6(Suppl 6):35-46.  

[2]. Hu LA, et al. Identification of surrogate agonists and antagonists for orphan G-protein-coupled receptor GPR139. J Biomol Screen. 2009 Aug;14(7):789-97.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H23NO2S

[ Molecular Weight ]:
329.46

Related Compounds