L-Methionine γ-lyase

Names

[ CAS No. ]:
42616-25-1

[ Name ]:
L-Methionine γ-lyase

Biological Activity

[Description]:

L-Methionine γ-lyase (Methionine lyase) is a multifunctional enzyme, which belongs to the γ-family of pyridoxal-5’-phosphate (PLP) dependent enzyme. L-Methionine γ-lyase can catylyse α, γ-elimunation of L-methionine and homocysteine. L-Methionine γ-lyase has anticancer and anti-infectious activity, and also can be used for homocysteinemia study[1][2][3].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Hendy MH, et al. Purification, Characterization and anticancer activity of L-methionine γ-lyase from thermo-tolerant Aspergillus fumigatus. Microb Cell Fact. 2023;22(1):8.  

[2]. Machover D, et al. Effects in Cancer Cells of the Recombinant l-Methionine Gamma-Lyase from Brevibacterium aurantiacum. Encapsulation in Human Erythrocytes for Sustained l-Methionine Elimination. J Pharmacol Exp Ther. 2019;369(3):489-502. doi:10.1124/jpet.119.256537  

[3]. Yoshimura M, et al. Formation of methyl mercaptan from L-methionine by Porphyromonas gingivalis. Infect Immun. 2000;68(12):6912-6916.  

Chemical & Physical Properties

[ Molecular Formula ]:
C9H14N2O12P2

[ Molecular Weight ]:
404.161182

[ Storage condition ]:
−20°C

Related Compounds