Grayanotoxin II

Names

[ CAS No. ]:
4678-44-8

[ Name ]:
Grayanotoxin II

[Synonym ]:
7-(prop-2-in-1-yloxy)-1-benzopyran-2-one
7-Propargyloxy-cumarin [German]
2H-1-Benzopyran-2-one,7-(2-propynyloxy)
(7R)-1,1,8-Trimethyl-4-methylen-(3ac,4at)-dodecahydro-7r,9ac-methano-cyclopenta[b]heptalen-2t,8c,11t,11at,12anti-pentaol
Grayanatoxin-II
Grayanotoxin-II
(3aR)-2c.8t.11c.11ac.12anti-Pentahydroxy-1.1.8c-trimethyl-4-methylen-(3arH.4acH)-tetradecahydro-7t.9at-methano-cyclopenta[b]heptalen
Andromedenol
(7-coumaryloxy)methylacetylene
(7R)-1,1,8-trimethyl-4-methylene-(3ac,4at)-dodecahydro-7r,9ac-methano-cyclopenta[b]heptalene-2t,8c,11t,11at,12anti-pentaol
(7-propargyloxy)coumarin
7-Propargyloxy-cumarin
7-(2-Propynyloxy)-2H-1-benzopyran-2-one
7-(prop-2-yn-1-yloxy)-2H-chromen-2-one

Biological Activity

[Description]:

Grayanotoxin II is a potent analgesic agent, is a diterpenoid. Grayanotoxin II shows significant analgesic activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vivo]

Grayanotoxin II (5 mg/kg; i.p.) 在乙酸诱导的小鼠扭体试验中显示出显着的镇痛活性[1]。 Animal Model: Kunming mice (acetic acid-induced writhing test)[1] Dosage: 5 mg/kg Administration: I.p. Result: Showed significant analgesic activity in mice.

[References]

[1]. Chang-Shan Niu, et al. Analgesic diterpenoids from the twigs of Pieris formosa. Tetrahedron. 2016, 72(1): 44-49.

Chemical & Physical Properties

[ Density]:
1.3g/cm3

[ Boiling Point ]:
522.9ºC at 760 mmHg

[ Molecular Formula ]:
C20H32O5

[ Molecular Weight ]:
352.46500

[ Flash Point ]:
237.9ºC

[ Exact Mass ]:
352.22500

[ PSA ]:
101.15000

[ LogP ]:
0.97350

[ Index of Refraction ]:
1.61

Safety Information

[ RIDADR ]:
UN 3172

[ Hazard Class ]:
6.1(a)

Related Compounds