Hexamethylphosphoramide-d18

Names

[ CAS No. ]:
51219-90-0

[ Name ]:
Hexamethylphosphoramide-d18

[Synonym ]:
Octadecadeuterio-hexamethyl-phosphoramide
EINECS 257-063-4
Hexamethylphosphortriamide-D18
DE650
hexakis-trideuteriomethyl-phosphamide

Biological Activity

[Description]:

Hexamethylphosphoramide-d18 is the deuterium labeled Hexamethylphosphoramide[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

Chemical & Physical Properties

[ Density]:
1.032g/cm3

[ Boiling Point ]:
233ºC at 760mmHg

[ Molecular Formula ]:
C6H18N3OP

[ Molecular Weight ]:
179.20000

[ Flash Point ]:
94.7ºC

[ Exact Mass ]:
179.11900

[ PSA ]:
36.60000

[ LogP ]:
0.77930

[ Index of Refraction ]:
1.464

[ Storage condition ]:
-20C

MSDS

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Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R45;R46

[ Safety Phrases ]:
S45-S53

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds