PDE4-IN-11

Names

[ CAS No. ]:
524734-30-3

[ Name ]:
PDE4-IN-11

Biological Activity

[Description]:

PDE4-IN-11 is an inhibitor of phosphodiesterase isoenzyme 4 (PDE4). PDE4-IN-11 displays highly effective bronchodilatory and anti-inflammatory properties, can be used for obstructive or inflammatory airway diseases research[1][2][3].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Inflammation/Immunology

[Target]

PDE4


[In Vitro]

PDE4-IN-11 (example 12) exerts function in the monocrotaline reversal model of pulmonary hypertension[2]. PDE4-IN-11 (compound A1) displays anti­inflammatory, anti-airways hyperreactivity and bronch odilator properties. PDE4-IN-11 also possesses immunosuppressive and TNFα secretion inhibitory activities[3].

[References]

[1]. Denholm A, et al. Preparation of naphthyridines as phosphodiesterase isoenzyme 4 (PDE4) inhibitors: World Intellectual Property Organization, WO2003039544[P]. 2003-05-15.

[2]. McCarthy C, et al. Use of naphthyridine derivatives as medicaments for the treatment of pulmonary hypertension: World Intellectual Property Organization, WO2007088019[P]. 2007-08-09.

[3]. Press NJ, et al. Organic compounds for treating pulmonary hypertension: World Intellectual Property Organization, WO2009013286. 2009-01-29.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H19FN2O2

[ Molecular Weight ]:
350.39

Related Compounds