Insulin-like growth factor II
Names
[ CAS No. ]:
67763-97-7
[ Name ]:
Insulin-like growth factor II
Biological Activity
[Description]:
Insulin-like growth factor II (IGF-2) is the principal somatomedin of human serum. Insulin-like growth factor II exerts permissive and direct effects on neurite outgrowth and enhances survival of sympathetic and sensory neurons[1][2].
[Related Catalog]:
[In Vitro]
Insulin-like growth factor II (IGF-2) (1-100 ng/mL; 24 h) 在 SH-SY5Y 细胞中以剂量依赖的方式显著增加了轴突承载细胞的百分比[2]。 Insulin-like growth factor II (IGF-2) (50 ng/mL; 1-24 h) 和 IGFBP2 联合使用增强了早期 IGF-1R 相关信号[2]。 Western Blot Analysis[2] Cell Line: SH-SY5Y cells Concentration: 50 ng/mL, alone or in combination with 50 ng/mL IGFBP2 Incubation Time: 1, 6, 12, or 24 h Result: Co-treatment increased IGF-1R phosphorylation within 1 h. Increased phosphorylated Akt (s473) within 12 h. Increased production of NF-L after 24 h.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C26H45N7O11
[ Molecular Weight ]:
631.68
[ Appearance of Characters ]:
lyophilized powder
[ Storage condition ]:
−20°C
Safety Information
[ WGK Germany ]:
3
[ RTECS ]:
NM8906000