3-acetyl-5-methoxy-1,4-dihydronaphthoquinone

Names

[ CAS No. ]:
81418-42-0

[ Name ]:
3-acetyl-5-methoxy-1,4-dihydronaphthoquinone

[Synonym ]:
3-Acetyl-5-methoxy-1,4-naphthoquinone
3-acetyl-5-methoxy-1,4-naphthoquinone
8-Methoxy-2-acetyl-naphthochinon-(1,4)
2-acetyl-8-methoxy-1,4-naphthoquinone

Biological Activity

[Description]:

SARS-CoV MPro-IN-2 (compound 15) is a potent inhibitor of SARS-CoV-2 Mpro with an IC50 value of 72.07 nM. The main protease (Mpro) of the virus as the major enzyme processing viral polyproteins contributes to the replication and transcription of SARS-CoV-2 in host cells, and has been characterized as an attractive target in drug discovery. SARS-CoV MPro-IN-2 has the potential for the research of COVID-19[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[References]

[1]. Cui J, et al. Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors. Eur J Med Chem. 2021;225:113789.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H10O4

[ Molecular Weight ]:
230.21600

[ Exact Mass ]:
230.05800

[ PSA ]:
60.44000

[ LogP ]:
1.58960

Precursor & DownStream

Precursor

DownStream

Related Compounds