P2X7 receptor antagonist-2

Names

[ CAS No. ]:
851269-75-5

[ Name ]:
P2X7 receptor antagonist-2

[Synonym ]:
1-Benzyl-N-(2,4-dichlorobenzyl)-5-oxo-3-pyrrolidinecarboxamide
3-Pyrrolidinecarboxamide, N-[(2,4-dichlorophenyl)methyl]-5-oxo-1-(phenylmethyl)-

Biological Activity

[Description]:

P2X7 receptor antagonist-2 is a potent P2X7 receptor antagonist with a pIC50 value of 6.5-7.5. P2X7 receptor antagonist-2 has efficacy of combating neuroinflammation[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor
Research Areas >> Neurological Disease

[Target]

pIC50：6.5-7.5 (P2X7 receptor)[1]


[References]

[1]. Steadman JGA, et, al. 5-oxo-3-pyrrolidinecarboxamide derivatives as p2x7 modulators. WO2009077559A2

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
640.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H18Cl2N2O2

[ Molecular Weight ]:
377.264

[ Flash Point ]:
340.9±31.5 °C

[ Exact Mass ]:
376.074524

[ LogP ]:
2.87

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.622

Related Compounds