PI3Kδ-IN-15

Names

[ Name ]:
PI3Kδ-IN-15

[Synonym ]:
4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)ethyl]-
5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)ethyl]-4(3H)-quinazolinone

Biological Activity

[Description]:

PI3Kδ-IN-15 (compound 6b) is a selective PI3Kδ inhibitor with an IC50 of 0.5 nM for p110δ. PI3Kδ-IN-15 inhibits PI3Kδ with >30-fold higher potency than PI3Kγ, PI3Kβ, and PI3Kα[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[Target]

p110δ:0.5 nM (IC50)

p110γ:15.3 nM (IC50)

p110β:145 nM (IC50)

p110α:152 nM (IC50)

[References]

[1]. Yeon Su Kim, et al. Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3Kδ-specific inhibitors for the treatment of hematologic malignancies. Bioorg Med Chem. 2021 Sep 1;45:116312.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₂₁H₁₆FN₇O

[ Molecular Weight ]:
401.40

[ Exact Mass ]:
401.140045

[ LogP ]:
2.43

[ Index of Refraction ]:
1.759