E3 ligase Ligand 9

Names

[ CAS No. ]:
87304-15-2

[ Name ]:
E3 ligase Ligand 9

[Synonym ]:
(S)-2-[(2S,3R)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid
N-Boc-bestain
N-Boc Bestatin

Biological Activity

[Description]:

E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[References]

[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H32N2O6

[ Molecular Weight ]:
408.48900

[ Exact Mass ]:
408.22600

[ PSA ]:
124.96000

[ LogP ]:
2.88060

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds