GPVI antagonist 2

Names

[ CAS No. ]:
880399-00-8

[ Name ]:
GPVI antagonist 2

Biological Activity

[Description]:

GPVI antagonist 2 (Compound 1) is a potential antagonist of Glycoprotein VI (GPVI). IC50 values of GPVI antagonist 2 are, respectively, 0.35 μM for collagen, 0.80 μM for CRP, 195.2 μM for convulxin and 81.38 μM for thrombin. Glycoprotein VI (GPVI) is a platelet major collagen receptor and a target for potent and safe antithrombotic research. GPVI antagonist 2 is a promising antiplatelet agent[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[References]

[1]. Olğaç S, et al. Identification of novel antiplatelet agents by targeting Glycoprotein VI: A combined virtual screening study. Bioorg Chem. 2022;121:105661.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H27N3O4

[ Molecular Weight ]:
421.49

Related Compounds