Mpro inhibitor N3

Mpro inhibitor N3 is a potent SARS-CoV-2 MPro inhibitor with an EC50 value of 16.77 µM. Mpro inhibitor N3 shows antiviral activities against HCoV-229E, FIPV, IBV and MHV-A59[1][2][3].

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

Mpro inhibitor N3 (0-100 µM) 具有抗病毒活性，对 SARS-CoV-2 的 EC50 值为 16.77 µM[1]。 Mpro inhibitor N3 (0-50 µM; 14 h) 抑制病毒生长，对 HCoV-229E、FIPV 和 MHV-A59 的 IC50 值分别为 4、8.8、2.7 µM[2]。

Mpro inhibitor N3 (0-0.64 µM; 3, 6 h) 在鸡胚胎中表现出抗 IBV 的抗病毒活性[3]。 Animal Model: Chicken embryos[3] Dosage: 0-0.64 µM Administration: 3, 6 h with 100-EID50 titer of IBV M41 virus Result: Showed that N3 is able to penetrate cells to inhibit the replication of IBV viruses, probably at the beginning of infection, with the PD50 of 0.13 μmol for the 3-h group and 0.17 μmol for the 6-h group.

[1]. Jin Z, et al. Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 2020 Jun;582(7811):289-293.  

[2]. Yang H, et al. Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS Biol. 2005 Oct;3(10):e324.  

[3]. Xue X, et al. Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design. J Virol. 2008 Mar;82(5):2515-27.