S-Me-DM4

Names

[ CAS No. ]:
890654-03-2

[ Name ]:
S-Me-DM4

Biological Activity

[Description]:

S-Me-DM4 is a metabolite of DM4 S-methylated by intracellular enzyme. DM4 (HY-100503) is a microtubule-depolymerizing maytansinoid with strong cytotoxicity. DM4 can be used as an ADC Cytotoxin molecule[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

[References]

[1]. Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73.  

Chemical & Physical Properties

[ Molecular Formula ]:
C39H56ClN3O10S

[ Molecular Weight ]:
794.39

Related Compounds