LY 163443

Names

[ CAS No. ]:
97581-70-9

[ Name ]:
LY 163443

[Synonym ]:
5-[4-(4-Acetyl-3-hydroxy-2-propylbenzyloxy)benzyl]-tetrazole
1-(2-Hydroxy-3-propyl-4-((4-(1H-tetrazol-5-ylmethyl)phenoxy)methyl)phenyl)ethanone
Ethanone,1-(2-hydroxy-3-propyl-4-((4-(1H-tetrazol-5-ylmethyl)phenoxy)methyl)phenyl)

Biological Activity

[Description]:

LY 163443 is a selective antagonist of leukotrienes D4 (LTD4) and E4 (LTE4). LY 163443 can antagonize LTD4-induced contractions of guinea pig ileum, trachea, and lung parenchyma. LY 163443 also inhibits tracheal contractions to LTE4[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor
Research Areas >> Inflammation/Immunology

[References]

[1]. Fleisch JH, et, al. Evaluation of LY163443, 1-[2-hydroxy-3-propyl-4-([4- (1H-tetrazol-5-ylmethyl)phenoxy]methyl) phenyl]ethanone, as a pharmacologic antagonist of leukotrienes D4 and E4. Naunyn Schmiedebergs Arch Pharmacol. 1986 May;333(1):70-7.  

[2]. Bitterman H, et, al. Use of a novel peptide leukotriene receptor antagonist, Ly-163443, in splanchnic artery occlusion shock. Prostaglandins Leukot Essent Fatty Acids. 1988 May;32(2):63-70.  

Chemical & Physical Properties

[ Density]:
1.259g/cm3

[ Boiling Point ]:
607.7ºC at 760 mmHg

[ Molecular Formula ]:
C20H22N4O3

[ Molecular Weight ]:
366.41400

[ Flash Point ]:
321.3ºC

[ Exact Mass ]:
366.16900

[ PSA ]:
100.99000

[ LogP ]:
3.23020

[ Index of Refraction ]:
1.615

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds