isodispar B

Names

[ CAS No. ]:
98192-64-4

[ Name ]:
isodispar B

[Synonym ]:
5,7-dihydroxy-8-(2-methyl-1-oxobutyl)-4-phenyl-2H-[1]benzopyran-2-one
5,7-dihydroxy-8-(3-methylbutyryl)-4-phenylcoumarin
8-(3-methylbutyryl)-4-phenyl-5,7-dihydroxycoumarin
5,7-dihydroxy-8-(3-methyl-butyryl)-4-phenyl-chromen-2-one

Biological Activity

[Description]:

Isodispar B is an anticancer agent that inhibits the proliferation of nasopharyngeal carcinoma and breast cancer cells and induces cell apoptosis. Isodispar B is cytotoxic to a wide range of cancer cell lines[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[In Vitro]

Isodispar B (化合物 1) (0-100 μM; 72 h) 具有广谱的抗癌活性，抑制细胞增殖，IC50 为 3.84-56.73 μM[1]。 Isodispar B (1 μM 和 10 μM; 3 d) 诱导鼻咽癌细胞 (TW01、CNE1、HK1、SUNE1) 凋亡[1]。 Cell Cytotoxicity Assay[1] Cell Line: Nasopharyngeal cancer cells (TW01, CNE1, HK1, and SUNE1) and noncancerous nasopharyngeal cells (NP460) Concentration: 0-100 μM Incubation Time: 72 hours Result: Showed cytotoxicity and inhibited cell viability with IC50s of 3.84 μM (SUNE1), 11.49 μM (TW01), 9.74 μM (CNE1), 5.58 μM (HK1), 56.73 μM (HCC38), 52.69 μM (MDA-MB-231), 52.75 μM (MDA-ME-468), and 54.85 μM (SKBR3), respectively.

[References]

[1]. Lim C K, et al. In vitro cytotoxic activity of isolated compounds from Malaysian Calophyllum species[J]. Medicinal Chemistry Research, 2016, 25(8): 1686-1694.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H18O5

[ Molecular Weight ]:
338.35400

[ Exact Mass ]:
338.11500

[ PSA ]:
87.74000

[ LogP ]:
4.10000

Related Compounds