Antibacterial agent 116

Names

[ CAS No. ]:
99330-28-6

[ Name ]:
Antibacterial agent 116

Biological Activity

[Description]:

Antibacterial agent 116 is a benzophenone-containing salicylanilide compound. Antibacterial agent 116 has potent antibacterial activity by inhibiting the peptidoglycan formation. Antibacterial agent 116 is used as a photoaffinity probe to label Acinetobacter baumannii penicillin-binding protein (PBP1b), block the propagation pathway to disrupt the growth of peptidoglycan chain[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Antibacterial agent 116 (compound 1) can photo-label A. baumannii PBP1b, targets to R367 and E372 binding site[1].

[References]

[1]. Chuang HC, et al. Photoaffinity labeling of benzophenone-containing salicylanilide compounds to give an insight into the mechanism in disrupting peptidoglycan formation. Bioorg Med Chem. 2022 Aug 1;67:116819. 

Chemical & Physical Properties

[ Molecular Formula ]:
C26H15Cl2I2NO4

[ Molecular Weight ]:
730.12

Related Compounds