Shanghai Nianxing Industrial Co., Ltd
China
Product Name: HDSF
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: AM374
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: hexadecanesulfonyl fluoride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: hexadecane-1-sulfonyl fluoride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

86855-26-7

86855-26-7 structure

86855-26-7 structure

Name: HDSF
Chemical Name: hexadecane-1-sulfonyl fluoride
CAS Number: 86855-26-7
Molecular Formula: C₁₆H₃₃FO₂S
Molecular Weight: 308.49500
Catalog: Signaling Pathways Metabolic Enzyme/Protease FAAH
Create Date: 2017-10-28 23:01:12
Modify Date: 2024-04-03 08:56:56
AM 374 is an fatty acid amide hydrolase (FAAH) inhibitor. AM 374 inhibits amidase activity with an IC50 value of 13 nM. AM 374 can be used for the research of neurological disease[1][2].

Name	hexadecane-1-sulfonyl fluoride
Synonyms	Hexadecanesulfonyl fluoride Hexadecylsulfonyl fluoride hdsf palmitylsulphonylfluoride Palmitylsulfonyl Fluoride AM 374 1-HEXADECYLSULFONYL FLUORIDE

Description	AM 374 is an fatty acid amide hydrolase (FAAH) inhibitor. AM 374 inhibits amidase activity with an IC50 value of 13 nM. AM 374 can be used for the research of neurological disease[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> FAAH
Target	IC50: 13 nM (amidase)[1]
In Vitro	AM 374 (0-9 nM) 抑制 N18TG2 细胞中 anandamide 分解[1]。
In Vivo	AM 374 (20 μg；心室内注射，1 次) 对 FR5 杠杆按压无影响，但与 anandamide (腹腔注射) 共同使用时减少杠杆按压[2]。 Animal Model: Adult male Sprague-Dawley rats with lever press training[2] Dosage: 20 μg Administration: Intraventricular (ICV) injection; 20 μg, once Result: Significantly reduced lever pressing when combined treatment with anandamide.
References	[1]. Deutsch DG, et al. Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor. Biochem Biophys Res Commun. 1997 Feb 3;231(1):217-21. [2]. Arizzi MN, et al. Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide. Life Sci. 2004 Jan 9;74(8):1001-11.

Density	0.966g/cm3
Boiling Point	388.3ºC at 760 mmHg
Molecular Formula	C₁₆H₃₃FO₂S
Molecular Weight	308.49500
Flash Point	188.6ºC
Exact Mass	308.21900
PSA	42.52000
LogP	6.84780
Index of Refraction	1.445
Storage condition	-20°C

HS Code	2904909090

38775-38-1 structure

38775-38-1

~96%

86855-26-7 structure

86855-26-7

Literature: Hyatt, John A.; White, Alan W. Synthesis, 1984 , # 3 p. 214 - 217

Precursor 1
38775-38-1
DownStream 1
86855-25-6

HS Code	2904909090
Summary	HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%