Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 12-Crown-4
Price:
Purity: 97.0%
Stocking Period: 10 Day
Contact: Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 12-Crown-4
Price: ￥268.0/1g ￥1278.0/5g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 12-crown-4
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 12-Crown-4
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 294-93-9 12-Crown-4
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

294-93-9

294-93-9 structure

Name: 12-Crown-4
Chemical Name: 12-crown-4
CAS Number: 294-93-9
Molecular Formula: C₈H₁₆O₄
Molecular Weight: 176.210
Catalog: Chemical reagent Organic reagent Ether
Create Date: 2018-05-26 08:00:00
Modify Date: 2024-01-01 19:12:36

Name	12-crown-4
Synonyms	12-crown-4 ether ethylene oxide cyclic tetramer 1,4,7,10-Tetraoxacyclododecane 12-Crown 4-Ether 12-Crown-4 12-Crown-4-ether 1,4,7,10-tetraoxa-cyclododecane EINECS 206-036-5 UNII-K6069P2C2A EOCT MFCD00005103

Density	1.0±0.1 g/cm3
Boiling Point	254.9±0.0 °C at 760 mmHg
Melting Point	16 °C(lit.)
Molecular Formula	C₈H₁₆O₄
Molecular Weight	176.210
Flash Point	120.1±30.0 °C
Exact Mass	176.104858
PSA	36.92000
LogP	-0.54
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.404
Storage condition	2-8°C
Water Solubility	MISCIBLE

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XF0550000

CHEMICAL NAME :: 1,4,7,10-Tetraoxacyclododecane

CAS REGISTRY NUMBER :: 294-93-9

BEILSTEIN REFERENCE NO. :: 1363064

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C8-H16-O4

MOLECULAR WEIGHT :: 176.24

WISWESSER LINE NOTATION :: T-12-O DO GO JOTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2830 mg/kg

TOXIC EFFECTS :: Behavioral - tremor

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 1,339,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1550 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3150 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 44,263,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1290 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4530 uL/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536186 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1 ppm/7H

SEX/DURATION :: male 15 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 27,342,1974

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 500 ppb/7H

SEX/DURATION :: male 15 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 27,342,1974

Hazard Codes	Xn:Harmful;
Risk Phrases	R20/21/22;R36/37/38
Safety Phrases	S28-S36/37-S45-S36-S26
RIDADR	UN 2810
WGK Germany	3
RTECS	XF0550000
Packaging Group	III
Hazard Class	6.1
HS Code	29329995

112-60-7

~30%

294-93-9

Literature: Tsunoda; Ozaki; Shirakata; Tamaoka; Yamamoto; Ito Tetrahedron Letters, 1996 , vol. 37, # 14 p. 2463 - 2466

112-60-7

~1%

294-93-9

33089-37-1

71092-59-6

Detail

Literature: Tetrahedron, , vol. 45, # 7 p. 2201 - 2212

112-60-7

~2%

294-93-9

33089-37-1

Literature: Bulletin of the Chemical Society of Japan, , vol. 53, # 6 p. 1689 - 1693

112-60-7

111-46-6

~0%

294-93-9

17455-13-9

Detail

Literature: Bulletin of the Chemical Society of Japan, , vol. 53, # 6 p. 1689 - 1693

107-21-1

112-26-5

~37%

294-93-9

Literature: Ziafati, Ahmad; Sabzevari, Omolbanin; Heravi, Majid M. Phosphorus, Sulfur and Silicon and the Related Elements, 2006 , vol. 181, # 4 p. 803 - 807

111-44-4

111-46-6

~24%

294-93-9

Literature: Bowsher, Brian R.; Rest, Antony J. Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1981 , p. 1157 - 1161

Precursor 5
112-60-7 111-46-6 107-21-1 112-26-5
111-44-4
DownStream 7
123-91-1 114094-11-0 16872-10-9 16390-61-7
40891-99-4 64028-03-1 5587-62-2

HS Code	29329995

294-93-9	82830-53-3
41775-76-2	114094-11-0
80403-59-4	294-92-8
14174-08-4	75507-19-6
53835-21-5	14696-05-0
1158522-08-7	1203165-51-8
940364-43-2	1157684-90-6
134104-43-1	131615-57-1
1208754-71-5	6906-52-1
930439-75-1	1568059-42-6