20261-85-2
20261-85-2 structure
- Name: Dinactin
- Chemical Name: nsc63925
- CAS Number: 20261-85-2
- Molecular Formula: C42H68O12
- Molecular Weight: 764.98200
- Catalog: Signaling Pathways Stem Cell/Wnt Wnt
- Create Date: 2017-11-10 19:46:24
- Modify Date: 2024-01-02 08:09:07
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Dinactin, an antibiotic ionophore produced by Streptomyces species, as an effective small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Dinactin shows marked inhibition of HCT-116 cell growth with an IC50 of 1.1 µM. Dinactin shows anti-proliferative activity against the cancer cells in apoptosis-independent manner. Dinactin is also an effective agent for the research of neuropathic pain[1].
| Name | nsc63925 |
|---|
| Description | Dinactin, an antibiotic ionophore produced by Streptomyces species, as an effective small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Dinactin shows marked inhibition of HCT-116 cell growth with an IC50 of 1.1 µM. Dinactin shows anti-proliferative activity against the cancer cells in apoptosis-independent manner. Dinactin is also an effective agent for the research of neuropathic pain[1]. |
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| Related Catalog | |
| In Vitro | Dinactin (compound 1) shows antibacterial activity with MIC values of 1, 0.039, 0.019, 0.078, 0.078, 0.156, 0.156, 0.156, 0.156 μg/ml for M.tuberculosis(ATCC 25177), S. epidermidis(ATCC 12228), M. luteus(ATCC10240), S. aureus(ATCC 35923), E. faecalis(ATCC 51299), B. subtilis(ATCC 11774), E. coli(ATCC 10536), P. aeruginosa(ATCC 10145), K. pneumonia(ATCC BAA-2146) strain, respectively[1]. Dinactin (0-100 µM) shows antitumor activity with IC50 values of 1.3, 1.1, 1.3, 1.5, 9.7, 80 µM for A549, HCT-116, T47D, MCF7, HepG2, HEK-293 cells, respectively[1]. Dinactin (0.5, 1, 2 µM; 24 h) induces morphological changes in a concentration dependent manner in HCT-116 cells[1]. inactin (0.5, 1, 2 µM; 24 h) effectively inhabits cell migration and invasion characteristics in HCT-116 cells[1]. |
| References |
| Density | 1.029g/cm3 |
|---|---|
| Boiling Point | 903.3ºC at 760 mmHg |
| Molecular Formula | C42H68O12 |
| Molecular Weight | 764.98200 |
| Flash Point | 354.9ºC |
| Exact Mass | 764.47100 |
| PSA | 142.12000 |
| LogP | 6.80220 |
| Vapour Pressure | 2.07E-33mmHg at 25°C |
| Index of Refraction | 1.45 |
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20261-85-2 |
| Literature: Ashworth, Doreen M.; Robinson, John A.; Turner, David L. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 1719 - 1728 |
| Precursor 1 | |
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| DownStream 0 | |