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40507-23-1

40507-23-1 structure
40507-23-1 structure
  • Name: Fluproquazone
  • Chemical Name: 4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one
  • CAS Number: 40507-23-1
  • Molecular Formula: C18H17FN2O
  • Molecular Weight: 296.33900
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2018-09-29 17:37:33
  • Modify Date: 2024-01-07 17:56:48
  • Fluproquazone is an analgesic that has analgesic properties[1].
Name 4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one
Synonyms fluproquazone
Fluproquazona [INN-Spanish]
4-(4-fluoro-phenyl)-1-isopropyl-7-methyl-1H-quinazolin-2-one
1-isopropyl-7-methyl-4-(p-fluorophenyl)-quinazolin-2(1H)-one
RF 46-790
1-isopropyl-4-(4-fluorophenyl)-7-methyl-2(1H)-quinazolinone
1-Isopropyl-7-methyl-4-(p-fluorophenyl)-2(1H)-quinazolinone
SaH 46-790
4-(p-Fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone
Tormosyl
Fluproquazonum [INN-Latin]
2(1H)-Quinazolinone,4-(p-fluorophenyl)-1-isopropyl-7-methyl
Description Fluproquazone is an analgesic that has analgesic properties[1].
Related Catalog
References

[1]. Wheatley D. Analgesic properties of fluproquazone. Rheumatol Rehabil. 1982 May;21(2):98-100.  

Density 1.18g/cm3
Boiling Point 436.6ºC at 760 mmHg
Molecular Formula C18H17FN2O
Molecular Weight 296.33900
Flash Point 217.9ºC
Exact Mass 296.13200
PSA 34.89000
LogP 4.09190
Index of Refraction 1.596

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA3401000
CHEMICAL NAME :
2(1H)-Quinazolinone, 4-(p-fluorophenyl)-1-isopropyl-7-methyl-
CAS REGISTRY NUMBER :
40507-23-1
BEILSTEIN REFERENCE NO. :
0891838
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C18-H17-F-N2-O
MOLECULAR WEIGHT :
296.37
WISWESSER LINE NOTATION :
T66 BNVNJ BY1&1 ER DF& I1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,882,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,882,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
650 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 34,879,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
742 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,882,1981 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
180 mg/kg
SEX/DURATION :
female 14 day(s) pre-mating female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,882,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,882,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1450 mg/kg
SEX/DURATION :
female 15-22 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,882,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
435 mg/kg
SEX/DURATION :
female 15-22 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,882,1981
HS Code 2933990090
7440-44-0 structure

7440-44-0
40507-24-2 structure

40507-24-2

~%

40507-23-1 structure

40507-23-1
Literature: Sandoz, Inc. Patent: US3937705 A1, 1976 ;
Precursor  2

DownStream  0

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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