341519-04-8

341519-04-8 structure

Name: H-p-Chloro-Phe-D-Cys-β-(3-pyridyl)-Ala-D-Trp-N-Me-Lys-Thr-Cys-2-Nal-NH2 trifluoroacetate salt (Disulfide bond)
Chemical Name: H-p-Chloro-Phe-D-Cys-β-(3-pyridyl)-Ala-D-Trp-N-Me-Lys-Thr-Cys-2-Nal-NH2
CAS Number: 341519-04-8
Molecular Formula: C₅₈H₇₁ClN₁₂O₉S₂
Molecular Weight: 1179.84000
Catalog: Signaling Pathways GPCR/G Protein Somatostatin Receptor
Create Date: 2017-01-19 07:20:10
Modify Date: 2024-01-08 17:32:07
PRL 3195 is a somatostatin receptor antagonist with Kis of 6, 17, 66, 1000 and 1000 nM for human somatostatin receptors (sst5, sst2, sst3, sst1 and sst4, respectively)[1].

Name	H-p-Chloro-Phe-D-Cys-β-(3-pyridyl)-Ala-D-Trp-N-Me-Lys-Thr-Cys-2-Nal-NH2
Synonyms	H-p-Chloro-Phe-D-Cys-b-(3-pyridyl)-Ala-D-Trp-N-Me-Lys-Thr-Cys-2-Nal-NH2

Description	PRL 3195 is a somatostatin receptor antagonist with Kis of 6, 17, 66, 1000 and 1000 nM for human somatostatin receptors (sst5, sst2, sst3, sst1 and sst4, respectively)[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor Signaling Pathways >> GPCR/G Protein >> Urotensin Receptor
Target	hsst5:6 nM (Ki) hsst2:17 nM (Ki) hsst3:66 nM (Ki) hsst1:1000 nM (Ki) hsst4:1000 nM (Ki) rat urotensin II receptor:429 nM (Ki) human urotensin II receptor:1846 nM (Ki)
In Vitro	PRL 3195 抑制人尿紧素 II (human urotensin II) 诱导的大鼠主动脉相位振荡，ED50 为 24 nM[1]。
References	[1]. Rossowski WJ, et al. Human urotensin II-induced aorta ring contractions are mediated by protein kinase C, tyrosine kinases and Rho-kinase: inhibition by somatostatin receptor antagonists. Eur J Pharmacol. 2002 Mar 8;438(3):159-70.