Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 2',2'-Difluoro-2'-deoxyuridine
Price: ￥1796.0/250mg ￥4496.0/1g ￥1126.0/100mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

114248-23-6

114248-23-6 structure

Name: 2',2'-Difluoro-2'-deoxyuridine
Chemical Name: 2',2'-Difluoro-2'-deoxyuridine
CAS Number: 114248-23-6
Molecular Formula: C₉H₁₀F₂N₂O₅
Molecular Weight: 264.183
Catalog: Biochemical Carbohydrate Monosaccharide
Create Date: 2018-09-21 17:48:49
Modify Date: 2024-01-09 13:03:20
2′,2′-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2′,2′-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro[1].

Name	2',2'-Difluoro-2'-deoxyuridine
Synonyms	2(1H)-Pyrimidinone, 1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)-4-hydroxy- 1-(2-Deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)-4-hydroxy-2(1H)-pyrimidinone Uridine, 2'-deoxy-2',2'-difluoro- Gemcitabine impurity C 2',2'-Difluoro-2'-deoxyuridine 2′,2′-difluorodeoxyuridine 2'-Deoxy-2',2'-difluorouridine

Description	2′,2′-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2′,2′-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Pauwels B, et al. The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitro. Cancer Chemother Pharmacol. 2006 Aug;58(2):219-28.

Density	1.7±0.1 g/cm3
Melting Point	147-149ºC
Molecular Formula	C₉H₁₀F₂N₂O₅
Molecular Weight	264.183
Exact Mass	264.055786
PSA	104.55000
LogP	-0.53
Index of Refraction	1.587
Storage condition	-20°C Freezer

143157-27-1

~94%

114248-23-6

Literature: ALIOS BIOPHARMA, INC.; Beigelman, Leonid; Wang, Guangyi; Smith, David Bernard; Deval, Jerome; Prhavc, Marija Patent: US2013/165400 A1, 2013 ; Location in patent: Paragraph 0420; 0421 ;

1201895-94-4

~91%

114248-23-6

Literature: Chou; Heath; Patterson; Poteet; Lakin; Hunt Synthesis, 1992 , # 6 p. 565 - 570

122111-03-9

114248-23-6

Literature: US2013/165400 A1, ;

1445381-44-1

114248-23-6

Literature: US2013/165400 A1, ;

103882-84-4

114248-23-6

Literature: Journal of Organic Chemistry, , vol. 53, # 11 p. 2406 - 2409

Precursor 4
143157-27-1 1201895-94-4 122111-03-9 103882-84-4
DownStream 0

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