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219773-55-4

219773-55-4 structure
219773-55-4 structure
  • Name: AS602868
  • Chemical Name: 1-[(5-methoxy-2-thiophen-2-ylquinazolin-4-yl)amino]-3-methylpyrrole-2,5-dione
  • CAS Number: 219773-55-4
  • Molecular Formula: C18H14N4O3S
  • Molecular Weight: 366.39
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2018-12-24 11:30:49
  • Modify Date: 2024-04-03 15:11:16
  • SPC 839 (compound 10) is an orally active inhibitor of AP-1 and NF-kB mediated transcriptional activation with IC50 of 0.008 μM[1].
Name 1-[(5-methoxy-2-thiophen-2-ylquinazolin-4-yl)amino]-3-methylpyrrole-2,5-dione
Synonyms a4715
spc-839
Description SPC 839 (compound 10) is an orally active inhibitor of AP-1 and NF-kB mediated transcriptional activation with IC50 of 0.008 μM[1].
Related Catalog
In Vivo SPC 839 (compound 10) (30 mg/kg, p.o., 21 days) 在佐剂诱导的关节炎大鼠模型中显示显著活性，使未注射足部肿胀减少 65%[1]。
References

[1]. Moorthy S S Palanki, et al. The design and synthesis of novel orally active inhibitors of AP-1 and NF-kappaB mediated transcriptional activation. SAR of in vitro and in vivo studies. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4077-80.   

Density 1.475
Molecular Formula C18H14N4O3S
Molecular Weight 366.39
Exact Mass 366.07900
PSA 115.89000
LogP 2.36870
5271-67-0 structure

5271-67-0

~%

219773-55-4 structure

219773-55-4

Literature: Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
53600-33-2 structure

53600-33-2

~%

219773-55-4 structure

219773-55-4

Literature: Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
219773-54-3 structure

219773-54-3

~%

219773-55-4 structure

219773-55-4

Literature: Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
219773-52-1 structure

219773-52-1

~%

219773-55-4 structure

219773-55-4

Literature: Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
219773-53-2 structure

219773-53-2

~%

219773-55-4 structure

219773-55-4

Literature: Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
Precursor  3

DownStream  0


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