AS602868

Modify Date: 2024-04-03 15:11:16

AS602868 structure	Common Name	AS602868
	CAS Number	219773-55-4	Molecular Weight	366.39
	Density	1.475	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₄N₄O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AS602868

SPC 839 (compound 10) is an orally active inhibitor of AP-1 and NF-kB mediated transcriptional activation with IC50 of 0.008 μM[1].

Name	1-[(5-methoxy-2-thiophen-2-ylquinazolin-4-yl)amino]-3-methylpyrrole-2,5-dione
Synonym	More Synonyms

Description	SPC 839 (compound 10) is an orally active inhibitor of AP-1 and NF-kB mediated transcriptional activation with IC50 of 0.008 μM[1].
Related Catalog	Research Areas >> Inflammation/Immunology
In Vivo	SPC 839 (compound 10) (30 mg/kg, p.o., 21 days) 在佐剂诱导的关节炎大鼠模型中显示显著活性，使未注射足部肿胀减少 65%[1]。
References	[1]. Moorthy S S Palanki, et al. The design and synthesis of novel orally active inhibitors of AP-1 and NF-kappaB mediated transcriptional activation. SAR of in vitro and in vivo studies. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4077-80.

Density	1.475
Molecular Formula	C₁₈H₁₄N₄O₃S
Molecular Weight	366.39
Exact Mass	366.07900
PSA	115.89000
LogP	2.36870

2-Thenoyl Chloride structure

2-Thenoyl Chloride

CAS#:5271-67-0

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AS602868 Structure

AS602868

CAS#:219773-55-4

Literature: Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080

2-Amino-6-methoxybenzoic acid structure

2-Amino-6-metho...

CAS#:53600-33-2

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AS602868 Structure

AS602868

CAS#:219773-55-4

Literature: Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080

4-chloro-5-methoxy-2-(2'-thienyl)quinazoline structure

4-chloro-5-meth...

CAS#:219773-54-3

~%

AS602868 Structure

AS602868

CAS#:219773-55-4

Literature: Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080

N/A structure

N/A

CAS#:219773-52-1

~%

AS602868 Structure

AS602868

CAS#:219773-55-4

Literature: Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080

5-Methoxy-2-(thiophen-2-yl)quinazolin-4-ol structure

5-Methoxy-2-(th...

CAS#:219773-53-2

~%

AS602868 Structure

AS602868

CAS#:219773-55-4

Literature: Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080

Precursor 3
CAS#:5271-67-0 2-Thenoyl Chloride CAS#:53600-33-2 2-Amino-6-metho... CAS#:219773-54-3 4-chloro-5-meth...
DownStream 0

a4715

spc-839

DC Chemicals Limited
China
Product Name: AS602868
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-(5-METHOXY-2-(THIOPHEN-2-YL)QUINAZOLIN-4-YLAMINO)-3-METHYL-1H-PYRROLE-2,5-DIONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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