AS602868

Modify Date: 2024-04-03 15:11:16

AS602868 Structure
AS602868 structure
 Common Name AS602868
CAS Number 219773-55-4 Molecular Weight 366.39
Density 1.475 Boiling Point N/A
Molecular Formula C18H14N4O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AS602868


SPC 839 (compound 10) is an orally active inhibitor of AP-1 and NF-kB mediated transcriptional activation with IC50 of 0.008 μM[1].

 Names

Name 1-[(5-methoxy-2-thiophen-2-ylquinazolin-4-yl)amino]-3-methylpyrrole-2,5-dione
Synonym More Synonyms

 AS602868 Biological Activity

Description SPC 839 (compound 10) is an orally active inhibitor of AP-1 and NF-kB mediated transcriptional activation with IC50 of 0.008 μM[1].
Related Catalog
In Vivo SPC 839 (compound 10) (30 mg/kg, p.o., 21 days) 在佐剂诱导的关节炎大鼠模型中显示显著活性，使未注射足部肿胀减少 65%[1]。
References

[1]. Moorthy S S Palanki, et al. The design and synthesis of novel orally active inhibitors of AP-1 and NF-kappaB mediated transcriptional activation. SAR of in vitro and in vivo studies. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4077-80.   

 Chemical & Physical Properties

Density 1.475
Molecular Formula C18H14N4O3S
Molecular Weight 366.39
Exact Mass 366.07900
PSA 115.89000
LogP 2.36870

 Synthetic Route

2-Thenoyl Chloride structure

2-Thenoyl Chloride

CAS#:5271-67-0

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AS602868 Structure

AS602868

CAS#:219773-55-4

Literature: Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
2-Amino-6-methoxybenzoic acid structure

2-Amino-6-metho...

CAS#:53600-33-2

~%

AS602868 Structure

AS602868

CAS#:219773-55-4

Literature: Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
4-chloro-5-methoxy-2-(2'-thienyl)quinazoline structure

4-chloro-5-meth...

CAS#:219773-54-3

~%

AS602868 Structure

AS602868

CAS#:219773-55-4

Literature: Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
5-Methoxy-2-(2-thienyl)-4H-3,1-benzoxazin-4-one structure

5-Methoxy-2-(2-...

CAS#:219773-52-1

~%

AS602868 Structure

AS602868

CAS#:219773-55-4

Literature: Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080
5-Methoxy-2-(thiophen-2-yl)quinazolin-4-ol structure

5-Methoxy-2-(th...

CAS#:219773-53-2

~%

AS602868 Structure

AS602868

CAS#:219773-55-4

Literature: Palanki, Moorthy S. S.; Erdman, Paul E.; Ren, Minghuan; Suto, Mark; Bennett, Brydon L.; Manning, Anthony; Ransone, Lynn; Spooner, Cheryl; Desai, Sonal; Ow, Arnie; Totsuka, Ryuichi; Tsao, Peter; Toriumi, Wataru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4077 - 4080

 Synonyms

a4715
spc-839
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