194160-45-7

194160-45-7 structure

194160-45-7 structure

Name: Fumaric acid-d4
Chemical Name: dideuterio (E)-2,3-dideuteriobut-2-enedioate
CAS Number: 194160-45-7
Molecular Formula: C₄D₄O₄
Molecular Weight: 120.09700
Create Date: 2018-02-26 08:00:00
Modify Date: 2024-01-03 20:23:35
Fumaric acid-d4 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].

Name	dideuterio (E)-2,3-dideuteriobut-2-enedioate
Synonyms	Fumaric acid-d4 MFCD00190450

Description	Fumaric acid-d4 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132(3):301-8.

Melting Point	299-300ºC (subl.)(lit.)
Molecular Formula	C₄D₄O₄
Molecular Weight	120.09700
Exact Mass	120.03600
PSA	74.60000

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport