260980-89-0

260980-89-0 structure

Name: Topilutamide
Chemical Name: (2R)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-[(2,2,2-trifluoroacetyl)amino]propanamide
CAS Number: 260980-89-0
Molecular Formula: C₁₃H₁₁F₆N₃O₅
Molecular Weight: 403.23400
Catalog: Research Areas Cancer
Create Date: 2017-07-09 13:49:59
Modify Date: 2024-01-08 18:03:39
Topilutamide is a topical nonsteroidal antiandrogen (NSAA).

Name	(2R)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-[(2,2,2-trifluoroacetyl)amino]propanamide
Synonyms	UNII-A8EU2FXY13 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(2,2,2-trifluoroacetylamino)propanamide Topilutamide

Description	Topilutamide is a topical nonsteroidal antiandrogen (NSAA).
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
In Vivo	Prostate cancer is the most common cancer and one of the leading causes of cancer deaths in men. One of the commonly used approaches to treat metastatic prostate cancer is via first-generation nonsteroidal anti-androgens (NSAAs), namely Flutamide, Nilutamide, Bicalutamide and Topilutamide[1].
References	[1]. Suresh PS, et al. Review of HPLC and LC-MS/MS assays for the determination of various nonsteroidal anti-androgens used in the treatment of prostate cancer. Biomed Chromatogr. 2017 Jun 21.