CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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UK4250000
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CHEMICAL NAME :
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Propyne
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CAS REGISTRY NUMBER :
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74-99-7
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BEILSTEIN REFERENCE NO. :
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0878138
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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29
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MOLECULAR FORMULA :
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C3-H4
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MOLECULAR WEIGHT :
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40.07
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WISWESSER LINE NOTATION :
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2UU1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LC - Lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>42000 ppm/6H
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TOXIC EFFECTS :
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Behavioral - general anesthetic Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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28700 ppm/6H/26W-I
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TOXIC EFFECTS :
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Behavioral - general anesthetic Lungs, Thorax, or Respiration - other changes Related to Chronic Data - death
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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28700 ppm/6H/26W-I
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - general anesthetic Gastrointestinal - changes in structure or function of salivary glands
MUTATION DATA
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TYPE OF TEST :
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Mutation in microorganisms
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TEST SYSTEM :
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Bacteria - Escherichia coli
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REFERENCE :
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MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 307,335,1994 *** REVIEWS *** ACGIH TLV-TWA 1640 mg/m3 (1000 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1000 ppm (1650 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,153,1971 OSHA PEL (Gen Indu):8H TWA 1000 ppm (1650 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1000 ppm (1650 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1000 ppm (1650 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1000 ppm (1650 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1000 ppm (1650 mg/m3);STEL 1250 ppm JAN 1993 OEL-BELGIUM:TWA 1000 ppm (1640 mg/m3);STEL 1250 ppm (2050 mg/m3) JAN 1993 OEL-DENMARK:TWA 1000 ppm (1650 mg/m3) JAN 1993 OEL-FINLAND:TWA 1000 ppm (1650 mg/m3);STEL 1250 ppm (2065 mg/m3) JAN 1993 OEL-FRANCE:TWA 1000 ppm (1650 mg/m3) JAN 1993 OEL-GERMANY:TWA 1000 ppm (1650 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 1000 ppm (1650 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 1000 ppm (1650 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 1000 ppm (1650 mg/m3) JAN 1993 OEL-TURKEY:TWA 1000 ppm (1650 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL ACETYLENE-air:10H TWA 1000 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 46435 No. of Facilities: 311 (estimated) No. of Industries: 9 No. of Occupations: 13 No. of Employees: 5033 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 46435 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 7 No. of Employees: 119 (estimated) No. of Female Employees: 6 (estimated)
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