Sichuan Hengkang Science and Technology Development Co.,Ltd.
China
Product Name: 4-Aminopyrazolo[3,4-d]pyrimidine
Price: ￥3500.0/1kg ￥3200.0/100kg ￥Inquiry/1000kg
Purity: 99.0%
Stocking Period: 7 Day
Contact: Teresa

DC Chemicals Limited
China
Product Name: Pyrazoloadenine
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Aminopyrazolo[3,4-d]pyrimidine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

2380-63-4

2380-63-4 structure

Name: 4-Aminopyrazolo[3,4-d]pyrimidine
Chemical Name: 4-Aminopyrazolo[3,4-d]pyrimidine
CAS Number: 2380-63-4
Molecular Formula: C₅H₅N₅
Molecular Weight: 193.671
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyrimidine compound Aminopyrimidine
Create Date: 2018-12-30 17:17:17
Modify Date: 2024-01-02 15:46:25
Pyrazoloadenine is a potent RET (REarranged during Transfection) lung cancer oncoprotein inhibitor. Pyrazoloadenine shows anticancer activity[1][2].

Name	4-Aminopyrazolo[3,4-d]pyrimidine
Synonyms	Methyl 3-piperidinylacetate hydrochloride (1:1) 7-deaza-8-aza-adenine 8-aza-7-deazaadenine 1H-Pyrazolo[3,4-d]pyrimidin-4-amine 1H-pyrazolo[3,4-d]pyrimidin-4-ylamine EINECS 219-174-6 pyrazolo[3,4-d]pyrimidin-4-amine Pyrazoloadenine Aminopurinol 4-aminopyrazolo-(3,4-d)pyrimidine 4-aminopyrazolo[5,4-d]pyrimidine 4-Aminopyrazolopyrimidine 1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine 4-Amino-1H-pyrazolo[3,4-d]pyrimidine Pyrazolo[3,4-d]pyrimidin-4-amin 4-app ADENINE ANTIMETABOLITE MFCD00005688 3-Piperidineacetic acid, methyl ester, hydrochloride (1:1) 4-AMINOPYRAZOLO{3,4-D}PYRIMIDINE 1(H)-4-amine-pyrazolo[3,4-d]pyrimidine 4-Amino pyrazolo[3,4-d]pyrimidine

Description	Pyrazoloadenine is a potent RET (REarranged during Transfection) lung cancer oncoprotein inhibitor. Pyrazoloadenine shows anticancer activity[1][2].
Related Catalog	Research Areas >> Cancer
In Vitro	Pyrazoloadenine inhibits a wide range of protein kinases such as BTK (Bruton’s tyrosine kinase), CDK1/2 (cyclin-dependent kinase 1/2), Src kinase, and RIPK1 (receptor-interacting protein kinase)[1].

Density	1.612g/cm3
Boiling Point	431.1ºC at 760mmHg
Melting Point	>325 °C(lit.)
Molecular Formula	C₅H₅N₅
Molecular Weight	193.671
Flash Point	244.4ºC
Exact Mass	193.086960
PSA	80.48000
LogP	0.51630
Storage condition	-20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UR0717000

CHEMICAL NAME :: 1H-Pyrazolo(3,4-d)pyrimidine, 4-amino-

CAS REGISTRY NUMBER :: 2380-63-4

BEILSTEIN REFERENCE NO. :: 0005824

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C5-H5-N5

MOLECULAR WEIGHT :: 135.15

WISWESSER LINE NOTATION :: T56 BMN GN INJ FZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 141 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ciliary spasm Sense Organs and Special Senses (Eye) - ptosis Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 228 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ciliary spasm Sense Organs and Special Senses (Eye) - ptosis Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ciliary spasm Sense Organs and Special Senses (Eye) - ptosis Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 181 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Gastrointestinal - changes in structure or function of salivary glands Kidney, Ureter, Bladder - urine volume increased

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 22500 mg/kg/9D-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Blood - changes in bone marrow (not otherwise specified) Blood - changes in platelet count

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 5 umol/L

REFERENCE :: ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 48,319,1967

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H315-H319-H335
Precautionary Statements	P261-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R23/24/25;R36/37/38
Safety Phrases	S26-S36/37/39-S45-S22
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	UR0717000
Packaging Group	III
Hazard Class	6.1
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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