Top Suppliers:I want be here
Related CAS#:
2519-30-4 81029-05-2
6104-59-2 630-98-8
5850-95-3 18015-76-4
6104-60-5 2610-15-3
10127-36-3 6379-02-8
1158522-08-7 940364-43-2
134104-43-1 131615-57-1
6906-52-1 120821-27-4
930439-75-1 1018584-77-4
1375289-11-4 849349-65-1

2519-30-4

2519-30-4 structure
2519-30-4 structure
  • Name: Brilliant Black BN
  • Chemical Name: Food Black 1
  • CAS Number: 2519-30-4
  • Molecular Formula: C28H17N5Na4O14S4
  • Molecular Weight: 867.679
  • Catalog: Biochemical Biochemical reagent Biological dye
  • Create Date: 2018-09-16 14:53:29
  • Modify Date: 2024-01-02 17:20:41
  • Brilliant black BN (E151) is an azo dye and a food colorant[1]. Brilliant black BN is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A. Brilliant black BN has the potential for the investigation of contagious disease[2].
Name Food Black 1
Synonyms Brilliant Black BN
EINECS 219-746-5
1743black
E151
blueblackbn
Tetrasodium 4-acetamido-5-hydroxy-6-({7-sulfonato-4-[(4-sulfonatophenyl)diazenyl]-1-naphthyl}diazenyl)-1,7-naphthalenedisulfonate
C.I. food black 1
l-schwarz1
Food Black 1
MFCD00078980
melanblack
Tetrasodium 1-acetamido-2-hydroxy-3-[4-[(4-sulphonatophenylazo)-7-sulphonato-1-naphthyl]azo]naphthalene-4,6-disulphonate
cilefablackb
BLACK PN
C.I. brilliant black BN
1,7-Naphthalenedisulfonic acid, 4-(acetylamino)-5-hydroxy-6-[2-[7-sulfo-4-[2-(4-sulfophenyl)diazenyl]-1-naphthalenyl]diazenyl]-, sodium salt (1:4)
WOOL BLACK
Brilliant Black PN
Description Brilliant black BN (E151) is an azo dye and a food colorant[1]. Brilliant black BN is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A. Brilliant black BN has the potential for the investigation of contagious disease[2].
Related Catalog
Target

IC50: 2.39 µM- 28.12 µM (various strains of EV71)[2]

In Vitro Brilliant black BN (E151) inhibits the interaction between EV71 and its cellular uncoating factor cyclophilin A [1]. Brilliant black BN (E151) inhibited the infection EV71 -GFP at a concentration of 300 µM as evidenced from the reduced GFP signals. Brilliant black BN (E151)exhibits the inhibition of EV71 -GFP as a dose-dependent manner in infected RD cells, exhibits an IC50 value of 10.1 µM[1]. Brilliant black BN (E151) is able to inhibit all tested 28 EV71, CVA16 and CVA6 strains. In rhabdomyosarcoma cells, 50% inhibitory concentration 29 of the dye E151 for various strains of EV71 ranged from 2.39 µM to 28.12 µM ,whereas its 50% cytotoxic concentration is 1870 µM [1].
In Vivo Brilliant black BN (E151)(intraperitoneal injection; 200 mg/kg; 14 days)exhibits mild illness with clinical scores less than 3 and subsequently recovered when compared with PBS-group.All E151 270 treated mice are completely protected throughout the experiment[1]. Animal Model: 14-days old AG129 mice with EV71[1] Dosage: 200 mg/kg Administration: Intraperitoneal injection Result: Had a Protective eddect on EV71 challenged AG129 mice by dye E151.
References

[1]. Lang W, et al. Biodecolorization of a food azo dye by the deep sea Dermacoccus abyssi MT1.1(T) strain from the Mariana Trench.J Environ Manage. 2014 Jan;132:155-64.

[2]. Meng T, et al. In Vitro and In Vivo Inhibition of the Infectivity of Human Enterovirus 71 by a Sulfonated Food Azo Dye, Brilliant Black BN.J Virol. 2019 Aug 13;93(17).
Molecular Formula C28H17N5Na4O14S4
Molecular Weight 867.679
Exact Mass 866.924561
PSA 361.09000
LogP 8.50040

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QJ5950000
CHEMICAL NAME :
1,7-Naphthalenedisulfonic acid, 4-acetamido-5-hydroxy-6-((7-sulfo-4-((p-sulfophenyl)a zo)- 1-naphthyl)azo)-, tetrasodium salt
CAS REGISTRY NUMBER :
2519-30-4
LAST UPDATED :
199504
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C28-H21-N5-O14-S4.4Na
MOLECULAR WEIGHT :
871.74
WISWESSER LINE NOTATION :
L66J BQ DSWQ GSWQ JMV1 CNUN- EL66J BNUNR DSWQ& HSWQ &-NA- 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 7,557,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 5,171,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 15,402,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 5,171,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 5,171,1967 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
162 gm/kg/90D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 5,171,1967 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1543 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2422 (estimated) No. of Female Employees: 384 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
RTECS QJ5950000

Chemsrc provides CAS#:2519-30-4 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 2519-30-4 | Chemsrc address: https://www.chemsrc.com/en/baike/1104233.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved