14215-68-0

14215-68-0 structure

Name: N-Acetyl-D-galactosamine
Chemical Name: N-acetyl-D-galactosamine
CAS Number: 14215-68-0
Molecular Formula: C₈H₁₅NO₆
Molecular Weight: 221.208
Catalog: Research Areas Others
Create Date: 2018-12-31 05:39:26
Modify Date: 2024-01-08 12:49:53
N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans. N-Acetyl-D-galactosamine (GalNAc) interact with Soya bean agglutinin (SBA), hence decreasing the effects of SBA on cellular membrane permeability and tight junction protein expression in piglets[1].N-Acetyl-D-galactosamine (GalNAc) inhibits the hemagglutinating activity by the lectin[2].

Name	N-acetyl-D-galactosamine
Synonyms	N-[(3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]acetamide EINECS 217-321-9 MFCD00065372 D-Galactopyranose, 2-(acetylamino)-2-deoxy- N-ACETEYL-D-GALACTOSAMINIDE N-Acetyl-D-galactosamine 2-(Acetylamino)-2-deoxy-D-galactopyranose N-acelyl-D-glucosamine 2-Acetamido-2-deoxy-D-galactose N-Acetylchondrosamine N-ACETYL-D-GALACTOSAMINIDE N-((3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide 2-Acetamido-2-deoxy-D-galactopyranose Hydrate 2-Acetamido-2-deoxy-D-galactopyranose ACETYL-D-GALACTOSAMINE N-Acetyl-D-chondrosamine Hydrate

Description	N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans. N-Acetyl-D-galactosamine (GalNAc) interact with Soya bean agglutinin (SBA), hence decreasing the effects of SBA on cellular membrane permeability and tight junction protein expression in piglets[1].N-Acetyl-D-galactosamine (GalNAc) inhibits the hemagglutinating activity by the lectin[2].
Related Catalog	Research Areas >> Others
In Vitro	N-Acetyl-D-galactosamine (GalNAc) (50nm; 4 hours) decreases the expression of occludin mRNA and claudin-3 mRNA by 1.6% and 2.7%[1]. N-Acetyl-D-galactosamine (GalNAc) (50nm; 4 hours) lowers the protein expression of occludin and claudin-3 by 4.3% and 7.2%, respectively[1]. RT-PCR[1] Cell Line: IPEC-J2 cell Concentration: 50 nM Incubation Time: 4 hours Result: Observed a slight reduction in mRNA expression of occludin and claudin-3. Western Blot Analysis[1] Cell Line: IPEC-J2 cell Concentration: 50 nM Incubation Time: 4 hours Result: Alleviated the damage of tight junction expressions at protein level.
References	[1]. Zhao B, et al. N-Acetyl-d-galactosamine prevents soya bean agglutinin-induced intestinal barrier dysfunction in intestinal porcine epithelial cells. J Anim Physiol Anim Nutr (Berl). 2019 Jul;103(4):1198-1206. [2]. Sadanandan R, et al. Isolation, Purification and Characterisation of a D-galactose and N-acetyl-D-galactosamineSpecific Lectin from Marine Sponge Fasciospongia cavernosa. Protein Pept Lett. 2018;25(9):871-877.

Density	1.5±0.1 g/cm3
Boiling Point	595.4±50.0 °C at 760 mmHg
Melting Point	158-162 °C
Molecular Formula	C₈H₁₅NO₆
Molecular Weight	221.208
Flash Point	313.9±30.1 °C
Exact Mass	221.089935
PSA	119.25000
LogP	-2.48
Vapour Pressure	0.0±3.8 mmHg at 25°C
Index of Refraction	1.576
Storage condition	2~8°C

Hazard Codes	Xi: Irritant;
Safety Phrases	S22-S24/25
WGK Germany	3

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