Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 11beta-Hydroxyprogesterone
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pregn-4-ene-3,20-dione,11-hydroxy-, (11b)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

600-57-7

600-57-7 structure

600-57-7 structure

Name: 11beta-Hydroxyprogesterone
Chemical Name: 11β-hydroxyprogesterone
CAS Number: 600-57-7
Molecular Formula: C₂₁H₃₀O₃
Molecular Weight: 330.46100
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-02-18 08:00:00
Modify Date: 2024-01-04 15:55:22
11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.

Name	11β-hydroxyprogesterone
Synonyms	11BETA-HYDROXYPROGESTERONE 4-PREGNEN-11BETA-OL-3,20-DIONE 21-deoxycorticosterone 11B-HYDROXYPROGESTERONE HYDROXYPROGESTERONE,11B 11beta-hydroxyprogesterone 4-PREGNEN-11BETA-3,20-DIONE

Description	11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.
Related Catalog	Natural Products >> Steroids Research Areas >> Cardiovascular Disease
Target	Human Endogenous Metabolite
In Vitro	11OHP displays agonist mineralocorticoid activity. 11β-hydroxyprogesterone activates the transiently expressed hMR in COS-7 cells in a dose-dependent manner with an ED50 of 10 nM and stimulates Ams/sc in mpkCCDcl4 cells. Docking 11β-hydroxyprogesterone within the hMR-ligand-binding domain homology model reveals that the agonist activity of 11OHP is caused by contacts between its 11β-hydroxyl group and Asn770[1].
In Vivo	11β-hydroxyprogesterone causes a significant elevation in blood pressure within 3 days, an effect that persisted throughout the 14-day infusion. 11β-hydroxyprogesterone is potently hypertensinogenic in the rat and that this activity depends on an intact adrenal and at least in part on the activation of mineralocorticoid receptors[2].
Animal Admin	Rats: 11α- and 11β-OHP are dissolved in propylene glycol (100%) and infused at 3 and 10 μg/h, respectively, for 14 days. Control rats received vehicle only. BP is measured the day before pumps were implanted and on days 3, 7, 10, and 14 after implantation. Indirect systolic BPs are measured with a modified tail-cuff method[2].
References	[1]. Rafestin-Oblin ME, et al. 11beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells. Mol Pharmacol. 2002 Dec;62(6):1306-13. [2]. Souness GW, et al. 11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat. Hypertension. 1996 Mar;27(3 Pt 1):421-5.

Density	1.15g/cm3
Boiling Point	487.4ºC at 760 mmHg
Molecular Formula	C₂₁H₃₀O₃
Molecular Weight	330.46100
Flash Point	262.7ºC
Exact Mass	330.21900
PSA	54.37000
LogP	3.69430
Index of Refraction	1.557
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5058000

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 11-beta-hydroxy-

CAS REGISTRY NUMBER :: 600-57-7

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H30-O3

MOLECULAR WEIGHT :: 330.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 28 mg/kg

SEX/DURATION :: female 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: JEMEAV Journal of Experimental Medicine. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1896- Volume(issue)/page/year: 102,347,1955

Precursor 9
55561-02-9 57524-89-7 516-15-4 2302-12-7
58761-31-2 57-83-0 58761-32-3 565-92-4
15807-40-6
DownStream 2
516-15-4 566-65-4