501-68-8

501-68-8 structure

501-68-8 structure

Name: Beclamide
Chemical Name: N-benzyl-3-chloropropanamide
CAS Number: 501-68-8
Molecular Formula: C₁₀H₁₂ClNO
Molecular Weight: 197.66100
Catalog: Research Areas Neurological Disease
Create Date: 2018-09-16 09:30:28
Modify Date: 2024-01-06 10:42:34
Beclamide is a drug that possesses anticonvulsant activity, has been used as a sedative and as an anticonvulsant.

Name	N-benzyl-3-chloropropanamide
Synonyms	Hibicon 3-Chlor-propionsaeure-benzylamid Neuracen 3-Chlor-N-benzyl-propionamid Chlorakon Nidrane Chloracon Beclamide 3-chloro-propionic acid benzylamide Posedrine Beklamid Nydran Nydrane

Description	Beclamide is a drug that possesses anticonvulsant activity, has been used as a sedative and as an anticonvulsant.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease

Density	1.145g/cm3
Boiling Point	386.9ºC at 760mmHg
Molecular Formula	C₁₀H₁₂ClNO
Molecular Weight	197.66100
Flash Point	187.8ºC
Exact Mass	197.06100
PSA	29.10000
LogP	2.32260
Index of Refraction	1.532

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UE3150000

CHEMICAL NAME :: Propionamide, N-benzyl-3-chloro-

CAS REGISTRY NUMBER :: 501-68-8

BEILSTEIN REFERENCE NO. :: 2720702

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H12-Cl-N-O

MOLECULAR WEIGHT :: 197.68

WISWESSER LINE NOTATION :: G2VM1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 107,403,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 770 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 107,403,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 770 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,384,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - anticonvulsant

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 14,99,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,384,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1368 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 28,452,1994

HS Code	2924299090

625-36-5 structure

625-36-5

100-46-9 structure

100-46-9

~70%

501-68-8 structure

501-68-8

Literature: Varie, David L.; Beck, Christopher; Borders, Sandra K.; Brady, Molly D.; Cronin, Jason S.; Ditsworth, Tracy K.; Hay, David A.; Hoard, David W.; Hoying, Richard C.; Linder, Ryan J.; Miller, Richard D.; Moher, Eric D.; Remacle, Jacob R.; Rieck III, John A.; Anderson, David D.; Dodson, Paul N.; Forst, Mindy B.; Pierson, Duane A.; Turpin, Joseph A. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 546 - 559

107-94-8 structure

107-94-8

100-46-9 structure

100-46-9

~54%

501-68-8 structure

501-68-8

Literature: Kumar, Amit; Akula, Hari Kiran; Lakshman, Mahesh K. European Journal of Organic Chemistry, 2010 , # 14 p. 2709 - 2715

79-10-7 structure

79-10-7

100-46-9 structure

100-46-9

~%

13304-62-6 structure

13304-62-6

501-68-8 structure

501-68-8

Literature: Cvetovich, Raymond J.; DiMichele, Lisa Organic Process Research and Development, 2006 , vol. 10, # 5 p. 944 - 946

Precursor 4
625-36-5 100-46-9 107-94-8 79-10-7
DownStream 2
13304-62-6 4458-64-4

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%