33421-40-8

33421-40-8 structure
33421-40-8 structure

Name 5-phenylpyridin-2-amine
Synonyms 5-phenyl-2-aminopyridine
5-phenyl-pyridin-2-ylamine
5-phenyl-2-pyridinamine
2-Amino-5-phenylpyridine
2-Pyridinamine,5-phenyl
5-Phenylpyridin-2-amine
MFCD01692452
Pyridine,2-amino-5-phenyl
Phe-P-1
Description 2-Amino-5-phenylpyridine is a mutagenic heterocyclic aromatic amine that is formed by pyrolysis of phenylalanine in proteins. 2-Amino-5-phenylpyridine is in broiled sardines and is considered as potentially carcinogenic[1][2].
Related Catalog
In Vitro On the other hand, the chemical structure of 5-phenyl-2-pyridinamine (PPA) shows a great resemblance to the aminobiphenyls, another well known class of carcinogenic aromatic amines[2].
References

[1]. Dooley KL, et al. Comparative carcinogenicity of the food pyrolysis product, 2-amino-5-phenylpyridine, and the known human carcinogen, 4-aminobiphenyl, in the neonatal B6C3F1 mouse. Cancer Lett. 1988 Jul;41(1):99-103.

[2]. Stavenuiter JF, et al. Syntheses of 5-phenyl-2-pyridinamine, a possibly carcinogenic pyrolysis product of phenylalanine, and some of its putative metabolites. Carcinogenesis. 1985 Jan;6(1):13-9.

Density 1.133g/cm3
Boiling Point 323.6ºC at 760mmHg
Melting Point 132 °C
Molecular Formula C11H10N2
Molecular Weight 170.21000
Flash Point 175.6ºC
Exact Mass 170.08400
PSA 38.91000
LogP 2.91200
Index of Refraction 1.625

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US2145000
CHEMICAL NAME :
Pyridine, 2-amino-5-phenyl-
CAS REGISTRY NUMBER :
33421-40-8
BEILSTEIN REFERENCE NO. :
0120219
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H10-N2
MOLECULAR WEIGHT :
170.23
WISWESSER LINE NOTATION :
T6NJ BZ FR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 26,611,1978
Hazard Codes Xn
Risk Phrases 36/37/38
Safety Phrases S26-S36/37/39
RTECS US2145000