42373-41-1

42373-41-1 structure

Name: ATP dipotassium
Chemical Name: adenosine 5'-triphosphate potassium salt
CAS Number: 42373-41-1
Molecular Formula: C₁₀H₁₄K₂N₅O₁₃P₃
Molecular Weight: 583.36200
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-10-02 10:48:42
Modify Date: 2024-01-05 11:19:09
ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation[1][2].

Name	adenosine 5'-triphosphate potassium salt
Synonyms	Adenosintriphosphat,Tetrakaliumsalz 5'-ATP-K2 ADENOSINE-5'-TRIPHOSPHATE DIPOTASSIUM SALT Adenosine 5'-(tetrahydrogen triphosphate),dipotassiuM salt adenosine 5'-triphosphate dipotassium*from bacter MFCD00084672 ADENOSINE 5'-TRIPHOSPHATE DIPOTASSIUMFRO M BACTERIA ATP POTASSIUM SALT

Description	ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
In Vitro	ATP dipotassium (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3]. ATP dipotassium (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner[4]. ATP dipotassium stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis[4].
In Vivo	ATP dipotassium (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4]. ATP dipotassium induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo[4]. Animal Model: Four-week-old Kunming mice (18-22 g)[4] Dosage: 50 mg/kg Administration: Intraperitoneal injection, before bacterial (E. coli) challenge Result: Protected mice from bacterial infection.
References	[1]. Bonora M, et al. ATP synthesis and storage. Purinergic Signal. 2012 Sep;8(3):343-57. [2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759.

Molecular Formula	C₁₀H₁₄K₂N₅O₁₃P₃
Molecular Weight	583.36200
Exact Mass	582.90800
PSA	314.22000

Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36

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