CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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TN4320000
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CHEMICAL NAME :
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Piperidine, 1,3,5-trimethyl-
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CAS REGISTRY NUMBER :
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27644-32-2
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LAST UPDATED :
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199203
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DATA ITEMS CITED :
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3
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MOLECULAR FORMULA :
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C8-H17-N
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MOLECULAR WEIGHT :
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127.26
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WISWESSER LINE NOTATION :
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T6NTJ A1 C1 E1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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500 mg/kg
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TOXIC EFFECTS :
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Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
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REFERENCE :
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AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 50,199,1903
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Amphibian - frog
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DOSE/DURATION :
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330 mg/kg
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TOXIC EFFECTS :
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Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Autonomic Nervous System - other (direct) parasympathomimetic Skin and Appendages - sweating
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REFERENCE :
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AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 50,199,1903
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Amphibian - frog
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DOSE/DURATION :
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375 mg/kg
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TOXIC EFFECTS :
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Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Lungs, Thorax, or Respiration - dyspnea
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REFERENCE :
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85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,595,1948
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