920035-77-4

920035-77-4 structure

Name: MK-4965
Chemical Name: 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chloroph enoxy}-5-chlorobenzonitrile
CAS Number: 920035-77-4
Molecular Formula: C₂₀H₁₃Cl₂N₅O₂
Molecular Weight: 426.26
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2017-09-27 01:47:31
Modify Date: 2024-01-03 15:52:34
MK-4965 is a nonnucleoside reverse transcriptase inhibitor (NNRTI). MK-4965 displays excellent activities against not only HIV-1 wild-type (WT) virus but also against a broad panel of NNRTI-resistant viruses and can be used for the research of HIV-1 infection[1].

Name	3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chloroph enoxy}-5-chlorobenzonitrile

Description	MK-4965 is a nonnucleoside reverse transcriptase inhibitor (NNRTI). MK-4965 displays excellent activities against not only HIV-1 wild-type (WT) virus but also against a broad panel of NNRTI-resistant viruses and can be used for the research of HIV-1 infection[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Anti-infection >> Reverse Transcriptase
Target	IC50: 0.23 nM (WT), 0.39 nM (Y181C), 0.40 nM (K103N)[1]
References	[1]. Lai MT, et al. Antiviral activity of MK-4965, a novel nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2009 Jun;53(6):2424-31.