1173435-64-7

1173435-64-7 structure

Name: BMS-665053
Chemical Name: 5-Chloro-1-[(1S)-1-cyclopropylethyl]-3-{[2,6-dichloro-4-(difluoro methoxy)phenyl]amino}-2(1H)-pyrazinone
CAS Number: 1173435-64-7
Molecular Formula: C₁₆H₁₄Cl₃F₂N₃O₂
Molecular Weight: 424.65700
Catalog: Signaling Pathways GPCR/G Protein CRFR
Create Date: 2017-10-04 18:50:38
Modify Date: 2024-01-05 19:43:07
BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM)[1].

Name	5-Chloro-1-[(1S)-1-cyclopropylethyl]-3-{[2,6-dichloro-4-(difluoro methoxy)phenyl]amino}-2(1H)-pyrazinone
Synonyms	1-Boc-D-Pyroglutamic acid ethyl ester Ethyl Boc-D-pyroglutamate Ethyl N-Boc-D-pyroglutamate

Description	BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM)[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CRFR Research Areas >> Neurological Disease
References	[1]. Jianqing Li, et al. An Efficient, Direct Bis-ortho-chlorination of 4-(Difluoromethoxy)aniline and Its Application to the Synthesis of BMS-665053, a Potent and Selective Pyrazinone-Containing Corticotropin-Releasing Factor-1 Receptor Antagonist. Organic Process Research & Development, 16, 156-159.