60398-23-4

60398-23-4 structure

Name: 6-Iodoamiloride
Chemical Name: 3,5-diamino-N-(diaminomethylidene)-6-iodopyrazine-2-carboxamide
CAS Number: 60398-23-4
Molecular Formula: C₆H₈IN₇O
Molecular Weight: 321.08
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2017-06-13 01:09:54
Modify Date: 2024-01-12 15:24:57
6-Iodoamiloride is a potent acid-sensing ion channel 1 (ASIC1) inhibitor with an IC50 of 88 nM. 6-Iodoamiloride inhibits ASIC3-mediated currents from rat dorsal root ganglion neurons with an IC50 of 230 nM[1].

Name	3,5-diamino-N-(diaminomethylidene)-6-iodopyrazine-2-carboxamide
Synonyms	3,5-diamino-6-iodo-pyrazine-2-carboxylic acid carbamimidoylamide N-Amidino-3,5-diamino-6-iodo-2-pyrazinecarboxamide 6-Iodoamiloride

Description	6-Iodoamiloride is a potent acid-sensing ion channel 1 (ASIC1) inhibitor with an IC50 of 88 nM. 6-Iodoamiloride inhibits ASIC3-mediated currents from rat dorsal root ganglion neurons with an IC50 of 230 nM[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cancer Research Areas >> Neurological Disease
Target	IC50: 88 nM (ASIC1)[1]
References	[1]. Rocio K Finol-Urdaneta, et al. Automated Patch Clamp Screening of Amiloride and 5- N, N-Hexamethyleneamiloride Analogs Identifies 6-Iodoamiloride as a Potent Acid-Sensing Ion Channel Inhibitor. Mol Pharm. 2023 Jul 3;20(7):3367-3379.

HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%