66537-55-1

66537-55-1 structure

Name: [2S-[2R*[R*(R*)]]]-N-[2-[4-(aminocarbonyl)-3-thiazolidinyl]-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl]-6-oxopiperidine-2-carboxamide
Chemical Name: (2S)-N-[(2S)-1-[(4S)-4-Carbamoyl-1,3-thiazolidin-3-yl]-3-(1H-imid azol-5-yl)-1-oxo-2-propanyl]-6-oxo-2-piperidinecarboxamide
CAS Number: 66537-55-1
Molecular Formula: C₁₆H₂₂N₆O₄S
Molecular Weight: 394.44900
Catalog: Research Areas Neurological Disease
Create Date: 2018-06-13 10:23:50
Modify Date: 2024-01-13 15:28:54
MK771 is a thyrotrophin-releasing hormone analog. MK771 induces blinking and forepaw licking. MK771 has the potential for the research of morphine abstinence syndrome[1][2].

Name	(2S)-N-[(2S)-1-[(4S)-4-Carbamoyl-1,3-thiazolidin-3-yl]-3-(1H-imid azol-5-yl)-1-oxo-2-propanyl]-6-oxo-2-piperidinecarboxamide
Synonyms	<>Aad-His-Tzl-NH2 {2S-[2R(R(R))]}-N-{2-[4-(aminocarbonyl)-3-thiazolidinyl]-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl}-6-oxopiperidine-2-carboxamide {2-Methyl-4-[bis-(2-jod-ethyl)-amino]-benzyliden}-malononitril {4-[bis(2-iodoethyl)amino]-2-methylbenzylidene}propanedinitrile

Description	MK771 is a thyrotrophin-releasing hormone analog. MK771 induces blinking and forepaw licking. MK771 has the potential for the research of morphine abstinence syndrome[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	MK771 (5 mg/kg；腹腔注射) 诱导小鼠眨眼和前爪舔[1]。 MK771 (10 ng-10 µg/小鼠；i.c.v.) 在小鼠体内产生高热反应[2]。 Animal Model: 20-30 g, male MF1 mice[1] Dosage: 5 mg/kg Administration: I.p. Result: Induced blinking and forepaw licking in both acutely isolated and paired mice. Animal Model: 20-30 g, male MF1 mice[1] Dosage: 0.25-60 mg/kg Administration: I.p. Result: Induced blinking was bell-shaped with an ED50 value of 1.72 mg/kg. Animal Model: 25-30 g, Male Swiss-Webster mice[2] Dosage: 10 ng-10 µg/mouse Administration: I.c.v. Result: Produced a hyperthermic response for 4 h followed by a return to normal temperature.
References	[1]. McCreary AC, et al. The thyrotrophin-releasing hormone analogue MK771 induces tic-like behaviours: the effects of dopamine D1 and D2 receptor antagonists. Eur J Pharmacol. 1999 Mar 12;369(1):1-9. [2]. Bhargava HN, et al. Comparative effects of thyrotropin releasing hormone, MK-771 and DN-1417 on morphine abstinence syndrome. Psychopharmacology (Berl). 1985;87(2):141-6.

77897-79-1

66537-55-1

Literature: Nutt; Holly; Homnick; Hirschmann; Veber; Arison Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 692 - 698

34622-39-4

66537-55-1

Literature: Nutt; Holly; Homnick; Hirschmann; Veber; Arison Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 692 - 698

77897-75-7

66537-55-1

Literature: Nutt; Holly; Homnick; Hirschmann; Veber; Arison Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 692 - 698

77897-78-0

66537-55-1

Literature: Nutt; Holly; Homnick; Hirschmann; Veber; Arison Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 692 - 698

77897-77-9

66537-55-1

Literature: Nutt; Holly; Homnick; Hirschmann; Veber; Arison Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 692 - 698