300-54-9

300-54-9 structure

Name: [2S-(2alpha,4beta,5alpha)]-[tetrahydro-4-hydroxy-5-methylfurfuryl]trimethylammonium
Chemical Name: [(2S,4R,5S)-4-hydroxy-5-methyloxolan-2-yl]methyl-trimethylazanium
CAS Number: 300-54-9
Molecular Formula: C₉H₂₀NO₂
Molecular Weight: 174.26100
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2016-11-27 05:23:42
Modify Date: 2024-02-05 20:13:25
Muscarine ((+)-Muscarine) is a toxin that can stimulate the parasympathetic nervous system. Muscarine is an agonist of muscarinic acetylcholine receptor (mAChR)[1][2].

Name	[(2S,4R,5S)-4-hydroxy-5-methyloxolan-2-yl]methyl-trimethylazanium
Synonyms	Muscarine (the alkaloid) Muscarin d,l-Muscarin L-(+)-Muscarine EINECS 206-094-1 (+)-(2S,4R,5S)-Muscarine Muscarine (alkaloid) Muskarin (+/-)-Muscarine

Description	Muscarine ((+)-Muscarine) is a toxin that can stimulate the parasympathetic nervous system. Muscarine is an agonist of muscarinic acetylcholine receptor (mAChR)[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
In Vitro	在脑微血管内皮细胞和小鼠脑微血管内皮细胞中，Muscarine (100 µM) 诱导的细胞内钙信号振幅与 10 µM 乙酰胆碱触发的信号振幅相似[1]。 Muscarine (1-30 μM；2 分钟) 在中缝大核 (NRM) 神经元上含有 5-羟色胺 (5-HT) 的 NRM 细胞亚群中产生剂量依赖性超极化，EC50 值为 2.7 µM[2]。
References	[1]. Beatrice Mihaela Radu, et al. All muscarinic acetylcholine receptors (M 1-M 5) are expressed in murine brain microvascular endothelium. Sci Rep. 2017 Jul 11;7(1):5083. [2]. Z Z Pan, et al. Muscarine hyperpolarizes a subpopulation of neurons by activating an M2 muscarinic receptor in rat nucleus raphe magnus in vitro. J Neurosci. 1994 Mar;14(3 Pt 1):1332-8.

Hazard Codes	Xn: Harmful;
Risk Phrases	22-36