88660-10-0

88660-10-0 structure

Name: Pipernonaline
Chemical Name: 9-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylnona-2,8-dien-1-one
CAS Number: 88660-10-0
Molecular Formula: C₂₁H₂₇NO₃
Molecular Weight: 341.44400
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2016-09-03 06:08:23
Modify Date: 2024-01-31 16:36:01
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization[1].

Name	9-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylnona-2,8-dien-1-one
Synonyms	Piperidine,1-[(2E,8E)-9-(1,3-benzodioxol-5-yl)-1-oxo-2,8-nonadienyl]

Description	Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Caspase
References	[1]. Lee W, et al. Pipernonaline from Piper longum Linn. induces ROS-mediated apoptosis in human prostate cancer PC-3 cells. Biochem Biophys Res Commun. 2013 Jan 4;430(1):406-12..

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H413
RIDADR	NONH for all modes of transport