102392-05-2

102392-05-2 structure

Name: 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-
Chemical Name: N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-phthalimide
CAS Number: 102392-05-2
Molecular Formula: C₂₃H₂₇N₃O₃
Molecular Weight: 393.48
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2017-11-26 08:09:57
Modify Date: 2024-01-02 20:00:47
NAN-190 is a serotonin receptor 5-HT antagonist. NAN-190 is a selective antagonist of 5-HT1A.Target: 5-HT in vitro: NAN-190 is a 5-HT1A antagonist. [3] NAN-190 is a selective antagonist of 5-HT1A. [1]in vivo: NAN-190 (0.5 mg/kg, ip), as a 5-HT1A receptor antagonist, is injected concomitantly with the effective dose of fluoxetine. NAN-190 (5-HT1A receptor antagonist) reverses the catalepsy-improving effect of fluoxetine in 6-OHDA lesioned rats. [2]

Name	N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-phthalimide
Synonyms	NAN 190 1-(2-methoxyphenyl)-4-(4-phthalimidobutyl)piperazine 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine hydrobromide 1-(methoxyphenyl)-4-<4-(2-phthalimido)butyl>-piperazine hydrobromide

Description	NAN-190 is a serotonin receptor 5-HT antagonist. NAN-190 is a selective antagonist of 5-HT1A.Target: 5-HT in vitro: NAN-190 is a 5-HT1A antagonist. [3] NAN-190 is a selective antagonist of 5-HT1A. [1]in vivo: NAN-190 (0.5 mg/kg, ip), as a 5-HT1A receptor antagonist, is injected concomitantly with the effective dose of fluoxetine. NAN-190 (5-HT1A receptor antagonist) reverses the catalepsy-improving effect of fluoxetine in 6-OHDA lesioned rats. [2]
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT1 Receptor
References	[1]. Shahane SA, et al. Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format. J Biomol Screen. 2014 Jan;19(1):66-76. [2]. Sharifi H, et al. Dose-Dependent Effect of Flouxetine on 6-OHDA-Induced Catalepsy in Male Rats: A Possible Involvement of 5-HT1A Receptors. Adv Pharm Bull. 2013;3(1):203-6. [3]. Citó MC, et al. Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system. Braz J Med Biol Res. 2015 Jan;48(1):57-64.

Precursor 0
DownStream 1
21103-33-3