838818-26-1

838818-26-1 structure

Name: WIKI4
Chemical Name: 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[3-[[4-(4-methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-
CAS Number: 838818-26-1
Molecular Formula: C₂₉H₂₃N₅O₃S
Molecular Weight: 521.590
Catalog: Biochemical Inhibitor Stem Cells & Wnt Signaling Paths (Stem Cells & Wnt) Wnt/beta-catenin inhibitor
Create Date: 2016-02-02 11:35:43
Modify Date: 2024-01-02 14:21:53
WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM); inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM).

Name	1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[3-[[4-(4-methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-
Synonyms	2-(3-{[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[3-[[4-(4-methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]- wiki4

Description	WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM); inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM).
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> β-catenin Research Areas >> Cancer
References	[1]. James RG, et al. WIKI4, a novel inhibitor of tankyrase and Wnt/?-catenin signaling. PLoS One. 2012;7(12):e50457.

Density	1.4±0.1 g/cm3
Boiling Point	783.1±70.0 °C at 760 mmHg
Molecular Formula	C₂₉H₂₃N₅O₃S
Molecular Weight	521.590
Flash Point	427.4±35.7 °C
Exact Mass	521.152161
PSA	117.20000
LogP	5.20
Appearance	white to beige
Vapour Pressure	0.0±2.7 mmHg at 25°C
Index of Refraction	1.716
Storage condition	?20°C
Water Solubility	DMSO: soluble10mg/mL, clear (warmed)

RIDADR	NONH for all modes of transport