957485-64-2
957485-64-2 structure
- Name: FPH2
- Chemical Name: 1H-Pyrazole-3-carboxamide, 4-[[[(5-chloro-2-methoxyphenyl)amino]thioxomethyl]amino]-1-ethyl-
- CAS Number: 957485-64-2
- Molecular Formula: C14H16ClN5O2S
- Molecular Weight: 353.82700
- Catalog: Research Areas Cancer
- Create Date: 2018-10-07 08:23:17
- Modify Date: 2024-01-02 08:41:14
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FPH2 induces of functional proliferation of primary human hepatocytes and may lead to the development of new therapeutics for liver diseases.
| Name | 1H-Pyrazole-3-carboxamide, 4-[[[(5-chloro-2-methoxyphenyl)amino]thioxomethyl]amino]-1-ethyl- |
|---|---|
| Synonyms |
FPH2
4-[[[(5-Chloro-2-methoxyphenyl)amino]thioxomethyl]amino]-1-ethyl-1H-pyrazole-3-carboxamide BRD-9424 |
| Description | FPH2 induces of functional proliferation of primary human hepatocytes and may lead to the development of new therapeutics for liver diseases. |
|---|---|
| Related Catalog | |
| In Vitro | FPH2 induces functional proliferation of hepatocytes in vitro, and thus may be useful for expanding mature human primary hepatocytes. FPH1 and FPH2 can increase in hepatocyte nuclei count and/or elevate the number of nuclei undergoing mitosis during primary screening, and these effects on hepatocytes are concentration dependent. Cells treated with FPH1 and FPH2 also maintain their liver-specific functions. Over 7 days, FPH2 induces hepatocyte doublings at a rate that is consistent with reported liver regeneration kinetics in vivo[1]. |
| References |
| Density | 1.45±0.1 g/cm3 |
|---|---|
| Molecular Formula | C14H16ClN5O2S |
| Molecular Weight | 353.82700 |
| Exact Mass | 353.07100 |
| PSA | 126.29000 |
| LogP | 3.31910 |
| Storage condition | -20℃ |
| Water Solubility | Practically insoluble (0.046 g/L) (25 ºC) |
| RIDADR | NONH for all modes of transport |
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